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The Lung Clearance Index (LCI) is an index derived from washout recordings, able to detect early peripheral airway damage in subjects with cystic fibrosis (CF) with a greater sensitivity than spirometry.
May 2, 2019
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What is a lung clearance index?
Lung clearance index (LCI) measured by multiple breath washout is a sensitive measure of ventilation inhomogeneity. Whereas FEV1 in health and early disease mostly reflects proximal airways, LCI is considered to reflect abnormalities of the smaller airways which are considered the site of early lung injury in CF.
What is normal LCI?
The small dependence of LCI on age is best summarised by a normal range (95% limits of normality) in adults of 5.9 to 7.5 and in children ((16 years) of 5.3 to 7.3.
How is LCI measured?
LCI is calculated as the cumulative exhaled volume at this point divided by the functional residual capacity (FRC), which is derived from the washout curve of the tracer gas.
Jan 30, 2019
What is Multiple breath Washout?
The multiple breath washout (MBW) test measures the efficiency of gas mixing in the lungs and has gained significant interest over the past 20 years. MBW outcomes detect early lung function impairment and peripheral airway pathology, through its main outcome measure lung clearance index (LCI).
Apr 1, 2022 · Lung clearance index (LCI) is accepted as an early marker of lung disease in cystic fibrosis (CF), however the utility of LCI to identify ...
Lung clearance index (LCI) measured by multiple breath washout is a sensitive measure of ventilation inhomogeneity. Whereas FEV1 in health and early disease ...
. Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis. Thorax 2008; ...
Apr 9, 2019 · Three-center feasibility of lung clearance index in infants and preschool children with cystic fibrosis and other lung diseases.
Apr 15, 2021 · Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in preschool children with cystic fibrosis (CF), but its ...
Jan 30, 2019 · The Lung Clearance Index has been used to demonstrate both progression of CF lung disease in young children1 and the response to several ...
Feb 3, 2021 · Lung Clearance Index (LCI) is a measure of ventilation distribution inhomogeneity. It can be calculated with the Multiple Breath Washout Method ...
Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis. Thorax, 2008;63:135–40], ...
Jul 19, 2015 · It has been suggested as a surrogate for chest computed tomography to detect structural lung abnormalities in individuals with cystic fibrosis ( ...
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