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+4 . To cause bodily discomfort or pain to ( a person ) ; to affect with pain or disease . Obs . a 1225 Ancr . R. 422 Hwon ze beoð ... 1833 Hr . MARTINEAU Charmed Sea i . ... +7 . intr . To feel annoyance or anger . Obs . 4 1300 Cursor M. 5949 Quen pharaon sagh rest and stund , His ... the streaming leaves . b . trans . To feel or show grief at or for ; to regret deeply . poet . 1598 DRAYTON Heroic . Ep . xvi .